Monomorphic Epitheliotropic Intestinal T-cell Lymphoma with Alveolar and Maxillary Metastases
A Case Report
DOI:
https://doi.org/10.21141/PJP.2026.483Keywords:
monomorphic epitheliotropic intestinal T-cell lymphoma, intestinal perforation, enteropathy-associated T-cell lymphoma type II, case reportAbstract
This is a case of monomorphic epitheliotropic intestinal T cell lymphoma presenting as ruptured viscous in a 64-year-old male. Monotonous cells were seen to infiltrate the full thickness of the bowel with immunoreactivity for CD3, CD8, CD56, CD68 and Granzyme B. The patient subsequently presented with maxillary and alveolar mass with similar immunohistomorphologic findings, suggesting metastasis. This rare disease has poor prognosis thus further reports should be conducted to profile this type of tumor.
Downloads
References
Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127(20):2375-90. https://pubmed.ncbi.nlm.nih.gov/26980727 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874220 https://doi.org/10.1182/blood-2016-01-643569
Chan JKC, Tan SY, de Leval L. Monomorphic epitheliotropic intestinal T-cell lymphoma. In: WHO Classification of Tumours Editorial Board, ed. Digestive System Tumours. 5th ed. Vol. 1. Lyon, France: International Agency for Research on Cancer; 2019.
Fei F, Reddy V, Patel CR, et al. Monomorphic epitheliotropic intestinal T-cell lymphoma: a study of four cases and review of literature. Ann Clin Lab Sci. 2020;50(6):806-12. https://pubmed.ncbi.nlm.nih.gov/33334797
Zhong H, Zheng Y, Zhang F. Monomorphic epitheliotropic intestinal T-cell lymphomas: a case report. Diagn Pathol. 2021;16(1):80. https://pubmed.ncbi.nlm.nih.gov/34461952 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8407069 https://doi.org/10.1186/s13000-021-01143-x
Shin SY. A rare case of intestinal T-cell lymphoma with multiple complications. J Diagn Case Rep. 2023;11(2):114-8. https://doi.org/10.52927/jdcr.2023.11.2.114
Veloza L, Cavalieri D, Missiaglia E, et al. Monomorphic epitheliotropic intestinal T-cell lymphoma comprises morphologic and genomic heterogeneity impacting outcome. Haematologica. 2023;108(1):181-95. https://pubmed.ncbi.nlm.nih.gov/35708139 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827163 https://doi.org/10.3324/haematol.2022.281226
Deleeuw RJ, Zettl A, Klinker E, et al. Whole-genome analysis and HLA genotyping of enteropathy-type T-cell lymphoma reveals 2 distinct lymphoma subtypes. Gastroenterology. 2007;132(5):1902-11. https://pubmed.ncbi.nlm.nih.gov/17484883 https://doi.org/10.1053/j.gastro.2007.03.036
Bhatlapenumarthi V, Patwari A, Siddiqui AD. An unusual case of enteropathy-associated T-cell lymphoma type 2 with pulmonary metastasis. Cureus. 2019;11(9):e5714. https://pubmed.ncbi.nlm.nih.gov/31720182 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823092 https://doi.org/10.7759/cureus.5714
Suzuki Y, Minemura H, Tomita H, et al. Monomorphic epitheliotropic intestinal T-cell lymphoma involving the lung and brain: a rare case study. Intern Med. 2020;59(20):2559-63. https://pubmed.ncbi.nlm.nih.gov/32641648 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662048 https://doi.org/10.2169/internalmedicine.4710-20
Muramoto K, Kaida S, Miyake T, et al. Rare monomorphic epithelial intestinal T-cell lymphoma of the stomach with a giant gastric perforation rescued by liver-covering sutures followed by a total gastrectomy and lateral hepatectomy: a case report. Surg Case Rep. 2022;8(1):27. https://pubmed.ncbi.nlm.nih.gov/35129729 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821748 https://doi.org/10.1186/s40792-022-01381-1
Ozaka S, Inoue K, Okajima T, et al. Monomorphic epitheliotropic intestinal T-cell lymphoma presenting as melena with long-term survival: a case report and review of literature. World J Gastroenterol. 2021;27(38):6501-10. https://pubmed.ncbi.nlm.nih.gov/34720538 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517785 https://doi.org/10.3748/wjg.v27.i38.6501
Huang D, Lim JQ, Cheah DMZ, et al. Whole-genome sequencing reveals potent therapeutic strategy for monomorphic epitheliotropic intestinal T-cell lymphoma. Blood Adv. 2020;4(19):4769-74. https://pubmed.ncbi.nlm.nih.gov/33017466 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556141 https://doi.org/10.1182/bloodadvances.2020001782
Chan JKC, Hyeh Y, Li GD, Takeuchi K. Extranodal NK/T-cell lymphoma. In: WHO Classification of Tumours Editorial Board, ed. Digestive System Tumours. 5th ed. Vol 1. Lyons, France: International Agency for Research on Cancer; 2019.
Zheng W, Gao Y, Ke X, et al. PEG-L-CHOP treatment is safe and effective in adult extranodal NK/T-cell lymphoma with a low rate of clinical hypersensitivity. BMC Cancer. 2018;18(1):910. https://pubmed.ncbi.nlm.nih.gov/30241515 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151061 https://doi.org/10.1186/s12885-018-4782-y
Luo F, Wang JN, Liu X, Wang X, Qi SN, Li YX. Efficacy of frontline chemotherapy for extranodal natural killer/T-cell lymphoma: a systematic review and network meta-analysis. J Hematol. 2023;12(5):215-26. https://pubmed.ncbi.nlm.nih.gov/37936976 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627360 DOI: 10.14740/jh1169
Alburqueque-Melgarejo J, Gárate BB, De la Cruz-Vargas JA. Epitheliotropic monomorphic intestinal T-cell lymphoma: case report and literature review. Curr Probl Cancer Case Rep. 2024;15(1):100313. DOI: 10.1016/j.cpccr.2024.100313.
Roberti A, Dobay MP, Bisig B, et al. Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations. Nat Commun. 2016;7:12602. https://pubmed.ncbi.nlm.nih.gov/27600764 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023950 https://doi.org/10.1038/ncomms12602
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Clarisse Anne Nuqui, Waldemar Siy, Karen Damian

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.









@philippinepathologyjournal