Disseminated Double-Hit Lymphoma in a Young Adult

Keywords: lymphoma, B-cell lymphoma, molecular diagnostic technique

Abstract

High-grade B-cell lymphoma with MYC and BCL2 and-or BCL6 rearrangements, also called double-hit lymphoma, is an aggressive mature B-cell lymphoma that carries both MYC and BCL2 and/or BCL6 translocations.  This can present as a diagnostic challenge since clinical characteristics, morphology and immunophenotype are not accurate indicators of underlying genetic aberrations in this type of lymphoma.  We report a case of a 25-year-old male who presented with a one-year history of cough, gradually increasing abdominal girth and jaundice.  Definitive diagnosis was made post-mortem with additional ancillary studies using immunohistochemistry staining and  fluorescent in-situ hybridization studies. 

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Author Biographies

Karen Damian, University of the Philippines-Philippine General Hospital

Consultant

Jonathan Emmanuel Cancio, University of the Philippines-Philippine General Hospital

Resident

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Published
2021-06-29
How to Cite
Damian, K., & Cancio, J. E. (2021). Disseminated Double-Hit Lymphoma in a Young Adult. PJP, 6(1), 56-61. https://doi.org/10.21141/PJP.2021.07
Section
Autopsy Vault