Infiltrative Basal Cell Carcinoma with Nodal Metastasis in a 74-year-old Female

A Case Report

Authors

  • Reynaldo Gabriel Paulino University of the Philippines-Philippine General Hospital, Manila https://orcid.org/0009-0006-4354-0308
  • John Ricardo Chua University of the Philippines-Philippine General Hospital, Manila
  • Karen Damian University of the Philippines, College of Medicine, Manila https://orcid.org/0000-0003-3634-3788
  • Erwin Gerard Geron University of the Philippines-Philippine General Hospital, Manila
  • Clarisse Veronica Mirhan University of the Philippines-Philippine General Hospital, Manila https://orcid.org/0009-0001-4647-7440

DOI:

https://doi.org/10.21141/PJP.2025.01

Keywords:

basal cell carcinoma, X-ray, squamous cell carcinoma in-situ, infiltrative basal cell carcinoma, basaloid cells

Abstract

Basal cell carcinoma, the most common human malignancy, has a rare incidence of metastases ranging from 0.0028-0.55%. We report a case of a 74-year-old female with a 10-year history of an enlarging anterior thigh nodule. Wide resection and inguinal lymph node dissection revealed an infiltrative basal cell carcinoma with lymph node metastasis due to the presence of basaloid cells, limited peripheral palisading, loose stroma, extensive spread, perineural invasion and immunoreactivity to p40, BerEP4, and GATA3.'

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Author Biographies

Reynaldo Gabriel Paulino, University of the Philippines-Philippine General Hospital, Manila

Department of Laboratories, University of the Philippines-Philippine General Hospital, Manila, Philippines

John Ricardo Chua, University of the Philippines-Philippine General Hospital, Manila

Department of Orthopaedics, University of the Philippines-Philippine General Hospital, Manila, Philippines

Karen Damian, University of the Philippines, College of Medicine, Manila

Department of Pathology, University of the Philippines, College of Medicine, Manila, Philippines

Erwin Gerard Geron, University of the Philippines-Philippine General Hospital, Manila

Department of Orthopaedics, University of the Philippines-Philippine General Hospital, Manila, Philippines

Clarisse Veronica Mirhan, University of the Philippines-Philippine General Hospital, Manila

1Department of Laboratories, University of the Philippines-Philippine General Hospital, Manila, Philippines

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Published

06/10/2025

How to Cite

Paulino, R. G., Chua, J. R., Damian, K., Geron, E. G., & Mirhan, C. V. (2025). Infiltrative Basal Cell Carcinoma with Nodal Metastasis in a 74-year-old Female: A Case Report. The Philippine Journal of Pathology, 10(1), 26–30. https://doi.org/10.21141/PJP.2025.01

Issue

Vol. 10 No. 1 (2025): June Issue (Online)

Section

Case Reports

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Copyright (c) 2025 Reynaldo Gabriel Paulino, Karen B. Damian, MD, FPSP, Clarisse Veronica L. Mirhan, RMT, MD, John Ricardo Chua, Erwin Gerard Geron

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.