Mixed Small Cell and Large Cell Neuroendocrine Carcinoma of the Endometrium
A Case Report and Literature Review
DOI:
https://doi.org/10.21141/PJP.2021.05Keywords:
Endometrial Neoplasms, Neuroendocrine Carcinoma, Large Cell Carcinoma, Small Cell CarcinomaAbstract
Neuroendocrine carcinoma (NEC) of the endometrium is a rare, aggressive subtype of endometrial cancer. We report a 61-year-old female with a history of breast cancer, s/p modified radical mastectomy, chemotherapy, radiotherapy and hormonal (tamoxifen) therapy, who presented with post-menopausal bleeding. Patient underwent TAH-BSO with lymph node dissection, and was diagnosed with a mixed small cell neuroendocrine carcinoma (SCNEC) and large cell neuroendocrine carcinoma (LCNEC), confirmed by positive immunohistochemical staining for neuroendocrine markers. No other lesions were identified on PET-CT, making a primary endometrial NEC the most likely diagnosis. We review the clinical and pathologic characteristics of endometrial neuroendocrine carcinomas.
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