Ovarian Carcinosarcoma with Yolk Sac Tumor in a Post-Menopausal Female

A Case Report and Review of Literature

  • Margarita Rae Rosario St. Luke's Medical Center, Quezon City, Philippines https://orcid.org/0000-0001-6484-5123
  • Jeffrey So St. Luke's Medical Center, Quezon City, Philippines
  • Claire Anne Therese Hemedez St. Luke's Medical Center, Quezon City, Philippines https://orcid.org/0000-0003-0791-1694
  • Carlos Dy St. Luke's Medical Center, Quezon City, Philippines
Keywords: carcinosarcoma, yolk sac tumor, ovary, postmenopausal

Abstract

Yolk sac tumor is the second most common subtype of ovarian germ cell tumors and is rare in postmenopausal
women. The few cases in literature have found that in this age group, yolk sac tumors more commonly present as a mixed component, combined with epithelial tumors. We report a case of a 60-year-old female who presented with an enlarging abdominopelvic mass. Imaging pointed to an ovarian new growth. Total abdominal hysterectomy with bilateral salpingo-oophorectomy revealed a tumor with three populations composed of carcinomatous, sarcomatous, and germ cell components, which was ultimately diagnosed as an ovarian carcinosarcoma with concurrent yolk sac tumor based on histomorphology and immunohistochemical staining. This report also discusses the proposed pathogenesis, treatment, and prognosis of this uncommon entity.

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Author Biographies

Margarita Rae Rosario, St. Luke's Medical Center, Quezon City, Philippines

Medical Resident, Institute of Pathology

Jeffrey So, St. Luke's Medical Center, Quezon City, Philippines

Consultant Anatomic Pathologist and Section Head, Histopathology

Institute of Pathology

Claire Anne Therese Hemedez, St. Luke's Medical Center, Quezon City, Philippines

Affiliate Member, Anatomic Pathology Consultant

Institute of Pathology

Carlos Dy, St. Luke's Medical Center, Quezon City, Philippines

Head, Cancer Institute

Consultant, Medical Oncology

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Published
2021-12-17
How to Cite
Rosario, M. R., So, J., Hemedez, C. A. T., & Dy, C. (2021). Ovarian Carcinosarcoma with Yolk Sac Tumor in a Post-Menopausal Female : A Case Report and Review of Literature. PJP, 6(2), 59-65. https://doi.org/10.21141/PJP.2021.18