Metaplastic Carcinoma with Mesenchymal Differentiation in Augmented Breast using Liquid Silicone Injection
A Case Report
DOI:
https://doi.org/10.21141/PJP.2020.10Keywords:
Metaplastic breast carcinoma, liquid silicone, breast augmentation, invasive breast carcinomaAbstract
The relationship between the use of liquid silicone for breast augmentation and carcinogenesis remains undetermined due to limited data reported, especially regarding its risks for acquiring cancer. We documented a case of an 81-year-old woman who presented with bilateral enlarging breast masses with a known history of breast augmentation using liquid silicone. On microscopic examination, the malignancy showed both mesenchymal and epithelial components in a background of stromal changes related to liquid silicone. Based from morphology and immunohistochemistry studies (p63, CK, HMW-CK, and CK5/6, CD34, and BcL-2), this case was signed out as metaplastic carcinoma with mesenchymal differentiation. This rare case of metaplastic carcinoma with mesenchymal differentiation coexisting with liquid silicone, provides evidence supporting the link between cancer development and siliconomas.
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References
1. Peters W, Fornasier V. Complications from injectable materials used for breast augmentation. Can J Plast Surg. 2009;17(3):89-96. https://www.ncbi.nlm.nih.gov/pubmed/20808751. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740603. https://doi.org/10.1177/229255030901700305
2. Morgenstern L, Gleischman S, Michel SL, Rosenberg JE, Knight I, Goodman D. Relation of free silicone to human breast carcinoma. Arch Surg. 1985;120(5):573-7. https://www.ncbi.nlm.nih.gov/pubmed/2985027. https://doi.org/10.1001/archsurg.1985.01390290051008.
3. Baluyut-Angeles KVA, Arcilla EPE. A Five-year retrospective study of the demographic distribution, clinical profile and treatment of patients with foreign body injections to the breast seen by the division of plastic surgery at the Philippine General Hospital. PJSS. 2011; 66(2):60-7. https://pcs.org.ph/assets/journals/PJSS-66-2-Apr-Jun-2011-4.pdf.
4. Bhosale SJ, Kshirsagar AY, Sulhyan SR, Sulhyan SR, Jagtap SV. Matrix-producing metaplastic breast carcinoma - a rare malignancy. Am J Case Rep. 2013;14:213-215. https://www.ncbi.nlm.nih.gov/pubmed/23826471. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700454. https://doi.org/10.1x2659/ajcr.883958.
5. Koufopoulos N, Kokkali S, Antoniadou F, Dimas DT, Missitzis IL. Matrix-producing breast carcinoma: a rare subtype of metaplastic breast carcinoma. Cureus. 2019;11(7):e5188. https://www.ncbi.nlm.nih.gov/pubmed/31565596. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758965. https://doi.org/10.7759/cureus.5188
6. WHO Classification of tumours Editorial Board. Breast tumours, 5th ed. Lyon France: International Agency
for Research on Cancer; 2019. https://publications.iarc.fr/581.
7. Rossi L, Paglicci C, Caprio G, et al. Matrix-producing carcinoma of the breast: a case report. Case Rep Oncol. 2013;6(2):245-9. https://www.ncbi.nlm.nih.gov/pubmed/23741218. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670645. https://doi.org/10.1159/000351119
8. Shruti S, Siraj F. Matrix-producing metaplastic breast carcinoma - a rare tumor with heterologous elements. Ger Med Sci. 2017;15:Doc17. https://www.ncbi.nlm.nih.gov/pubmed/29255401. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727344. https://doi.org/10.3205/000258.
9. Rosen's breast pathology, 4th ed. Philadelphia, PA:Lippincott Williams & Wilkins; 2014
10. Handel N, Silverstein MJ. Breast cancer diagnosis and prognosis in augmented women. Plast Reconstr Surg.
2006;118(3):587-93; discussion 594-6. https://www.ncbi.nlm.nih.gov/pubmed/16932162. https://doi.org/10.1097/01.prs.0000233038.47009.04
11. Cheung YC, Lee KF, Ng SH, Chan SC, Wong AM. Sonographic features with histologic correlation in two cases of palpable breast cancer after breast augmentation by liquid silicone injection. J Clin Ultrasound. 2002;30(9): 548-51. https://www.ncbi.nlm.nih.gov/pubmed/12404521. https://doi.org/10.1002/jcu.10110.
12. Tanaka Y, Morishima I, Kikuchi K. Invasive micropapillary carcinomas arising 42 years after augmentation mammoplasty: a case report and literature review. World J Surg Oncol. 2008;6:33. https://www.ncbi.nlm.nih.gov/pubmed/18341700. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292720. https://doi.org/10.1186/1477-7819-6-33.
13. Stivala A, Libra M, Stivala F, Perrotta R. Breast cancer risk in women treated with augmentation mammoplasty (review). Oncol Rep. 2012; 28(1):3-7. https://www.ncbi.nlm.nih.gov/pubmed/22576794. https://doi.org/10.3892/or.2012.1762.
14. Nakahori R, Takahashi R, Akashi M, et al. Breast carcinoma originating from a silicone granuloma: a case report. World J Surg Oncol. 2015;13:72. https://www.ncbi.nlm.nih.gov/pubmed/25888835. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350903. https://doi.org/10.1186/s12957-015-0509-6.
15. McMullen ER, Zoumberos NA, Kleer CG. Metaplastic breast carcinoma: update on histopathology and
molecular alterations. Arch Pathol Lab Med. 2019;143(12):1492-6. https://www.ncbi.nlm.nih.gov/pubmed/31765246. https://doi.org/10.5858/arpa.2019-0396-RA.
2. Morgenstern L, Gleischman S, Michel SL, Rosenberg JE, Knight I, Goodman D. Relation of free silicone to human breast carcinoma. Arch Surg. 1985;120(5):573-7. https://www.ncbi.nlm.nih.gov/pubmed/2985027. https://doi.org/10.1001/archsurg.1985.01390290051008.
3. Baluyut-Angeles KVA, Arcilla EPE. A Five-year retrospective study of the demographic distribution, clinical profile and treatment of patients with foreign body injections to the breast seen by the division of plastic surgery at the Philippine General Hospital. PJSS. 2011; 66(2):60-7. https://pcs.org.ph/assets/journals/PJSS-66-2-Apr-Jun-2011-4.pdf.
4. Bhosale SJ, Kshirsagar AY, Sulhyan SR, Sulhyan SR, Jagtap SV. Matrix-producing metaplastic breast carcinoma - a rare malignancy. Am J Case Rep. 2013;14:213-215. https://www.ncbi.nlm.nih.gov/pubmed/23826471. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700454. https://doi.org/10.1x2659/ajcr.883958.
5. Koufopoulos N, Kokkali S, Antoniadou F, Dimas DT, Missitzis IL. Matrix-producing breast carcinoma: a rare subtype of metaplastic breast carcinoma. Cureus. 2019;11(7):e5188. https://www.ncbi.nlm.nih.gov/pubmed/31565596. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758965. https://doi.org/10.7759/cureus.5188
6. WHO Classification of tumours Editorial Board. Breast tumours, 5th ed. Lyon France: International Agency
for Research on Cancer; 2019. https://publications.iarc.fr/581.
7. Rossi L, Paglicci C, Caprio G, et al. Matrix-producing carcinoma of the breast: a case report. Case Rep Oncol. 2013;6(2):245-9. https://www.ncbi.nlm.nih.gov/pubmed/23741218. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670645. https://doi.org/10.1159/000351119
8. Shruti S, Siraj F. Matrix-producing metaplastic breast carcinoma - a rare tumor with heterologous elements. Ger Med Sci. 2017;15:Doc17. https://www.ncbi.nlm.nih.gov/pubmed/29255401. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727344. https://doi.org/10.3205/000258.
9. Rosen's breast pathology, 4th ed. Philadelphia, PA:Lippincott Williams & Wilkins; 2014
10. Handel N, Silverstein MJ. Breast cancer diagnosis and prognosis in augmented women. Plast Reconstr Surg.
2006;118(3):587-93; discussion 594-6. https://www.ncbi.nlm.nih.gov/pubmed/16932162. https://doi.org/10.1097/01.prs.0000233038.47009.04
11. Cheung YC, Lee KF, Ng SH, Chan SC, Wong AM. Sonographic features with histologic correlation in two cases of palpable breast cancer after breast augmentation by liquid silicone injection. J Clin Ultrasound. 2002;30(9): 548-51. https://www.ncbi.nlm.nih.gov/pubmed/12404521. https://doi.org/10.1002/jcu.10110.
12. Tanaka Y, Morishima I, Kikuchi K. Invasive micropapillary carcinomas arising 42 years after augmentation mammoplasty: a case report and literature review. World J Surg Oncol. 2008;6:33. https://www.ncbi.nlm.nih.gov/pubmed/18341700. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292720. https://doi.org/10.1186/1477-7819-6-33.
13. Stivala A, Libra M, Stivala F, Perrotta R. Breast cancer risk in women treated with augmentation mammoplasty (review). Oncol Rep. 2012; 28(1):3-7. https://www.ncbi.nlm.nih.gov/pubmed/22576794. https://doi.org/10.3892/or.2012.1762.
14. Nakahori R, Takahashi R, Akashi M, et al. Breast carcinoma originating from a silicone granuloma: a case report. World J Surg Oncol. 2015;13:72. https://www.ncbi.nlm.nih.gov/pubmed/25888835. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350903. https://doi.org/10.1186/s12957-015-0509-6.
15. McMullen ER, Zoumberos NA, Kleer CG. Metaplastic breast carcinoma: update on histopathology and
molecular alterations. Arch Pathol Lab Med. 2019;143(12):1492-6. https://www.ncbi.nlm.nih.gov/pubmed/31765246. https://doi.org/10.5858/arpa.2019-0396-RA.
Published
12/16/2020
How to Cite
Lorenzo, L. M., Datay-Lim, S. J., & Carnate, J. (2020). Metaplastic Carcinoma with Mesenchymal Differentiation in Augmented Breast using Liquid Silicone Injection: A Case Report. PJP, 5(2), 47–52. https://doi.org/10.21141/PJP.2020.10
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Section
Case Reports
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The Philippine Journal of Pathology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on works made open access at http://philippinejournalofpathology.org
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