Corticosteroid-associated Changes Resembling a Demyelinating Brain Lesion in Diffuse Large B-cell Lymphoma (DLBCL)

A Case Report

Keywords: corticosteroids, demyelination, diffuse large B-cell, lymphoma

Abstract

Biopsies of suspected lymphoma cases with history of pre-biopsy corticosteroid therapy present several diagnostic issues, such as the inability to demonstrate the neoplastic hematolymphoid cells, the similarity of post-corticosteroid changes with inflammatory demyelinating lesions, and the possibility of a demyelinating lesion preceding a central nervous system lymphoma. This report presents the case of a 51-year-old immunocompetent male with a solitary callosal mass, with immunomorphologic features suggestive of a demyelinating lesion on initial biopsy, and upon re-biopsy after three months revealed a diffuse large B-cell lymphoma. Awareness of these issues in post-corticosteroid stereotactic biopsy specimens, together with adequate clinical and radiologic data, is important for proper diagnosis and further therapeutic guidance.

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Author Biographies

Gio Earnest de la Cruz, The Medical City, Pasig City, Philippines

Department of Laboratory Medicine and Pathology

Justine Alessandra Uy, The Medical City, Pasig City, Philippines

Department of Laboratory Medicine and Pathology

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Published
2021-09-07
How to Cite
de la Cruz, G. E., & Uy, J. A. (2021). Corticosteroid-associated Changes Resembling a Demyelinating Brain Lesion in Diffuse Large B-cell Lymphoma (DLBCL): A Case Report. PJP, 6(2). Retrieved from https://philippinejournalofpathology.org/index.php/PJP/article/view/255