A Case of Dentinogenic Ghost Cell Tumor

Authors

  • Jon Michael Vincent Soon The Medical City, Pasig City, Philippines https://orcid.org/0000-0002-1640-7257
  • Jose Carnate Jr. The Medical City, Pasig City, Philippines

DOI:

https://doi.org/10.21141/PJP.2021.02

Keywords:

dentinogenic ghost cell tumor, odontogenic cyst, ghost cells, odontogenic tumors

Abstract

Among the ghost cell lesions, Dentinogenic Ghost Cell Tumors (DGCT) are among the rarest. We report a case of a 45-year-old Filipino man, who presented with a right mandibular mass. Microscopic examination showed a solid neoplasm composed of islands of odontogenic epithelium with areas showing aberrant keratinization forming ghost cells and dentinoid material. We also discuss the pertinent differential diagnosis of ghost cell-containing odontogenic tumors. We report this case due to its rarity, its morphological resemblance to ameloblastoma, and its potential for malignant transformation.

 

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Author Biographies

Jon Michael Vincent Soon, The Medical City, Pasig City, Philippines

Department of Laboratory Medicine and Pathology

Jose Carnate Jr., The Medical City, Pasig City, Philippines

Department of Laboratory Medicine and Pathology, The Medical City, Pasig City, Philippines

Department of Pathology, College of Medicine,  University of the Philippines Manila

References

1. Carlos R, Ledesma-Montes C. Dentinogenic ghost cell tumour. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. WHO classification of head and neck tumors, 4th ed. IARC: Lyon; 2017.

2. Bafna SS, Joy T, Tupkari JV, Landge JS. Dentinogenic ghost cell tumor. J Oral Maxillofac Pathol. 2016;20(1):163. PMID: 27194885. PMCID: PMC4860925. https://doi.org/10.4103/0973-029X.180985.

3. Bilodeau EA, Prasad JL, Alawi F, Seethala RR. Molecular and genetic aspects of odontogenic lesions. Head Neck Pathol. 2014;8(4):400–10. PMID: 25409852. PMCID: PMC4245404. https://doi.org/10.1007/s12105-014-0588-7.

4. Kim SA, Ahn SG, Kim SG, et al. Investigation of the β-catenin gene in a case of dentinogenic ghost cell tumor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103(1):97–101. PMID: 17178501. https://doi.org/10.1016/j.tripleo.2005.10.037.

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Published

08/05/2021

How to Cite

Soon, J. M. V., & Carnate Jr., J. (2021). A Case of Dentinogenic Ghost Cell Tumor. The Philippine Journal of Pathology, 6(2), 38–40. https://doi.org/10.21141/PJP.2021.02

Issue

Vol. 6 No. 2 (2021): December Issue (Online)

Section

Case Reports

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