Calcifying Fibrous Tumor of the Jejunum in a 27-year-old Primigravid
A Case Report
DOI:
https://doi.org/10.21141/PJP.2020.05Keywords:
calcifying fibrous tumor, jejunum, neoplasms, fibrous tissueAbstract
The most common mesenchymal tumors of the gastrointestinal tract are gastrointestinal stromal tumors (GIST) and smooth muscle neoplasms; however, other soft tissue tumors may also present in the intestines and cause diagnostic dilemmas. We report the case of a 27-year old primigravid, with no known complications, who underwent cesarean section for cephalopelvic disproportion. Intraoperatively, a well-demarcated, solid mass measuring 1.5 x 1.0 x 0.7 cm was noted at the jejunum. The patient underwent segmental resection of the mass. Microscopic examination of the mass reveals a non-encapsulated, solid mass composed of bland spindle cells and dense, hyalinized collagen in whorls and bundles. Dystrophic calcifications and a lymphoplasmacytic inflammatory infiltrate are seen within the collagen bundles. Immunohistochemical staining with desmin, CD117, and DOG-1 was done, which are all negative. The case was signed out as calcifying fibrous tumor (CFT). Inclusion of CFTs in the differential diagnoses for mesenchymal tumors of the gastrointestinal tract is important, as these neoplasms are benign and have an excellent prognosis.
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2. Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F. WHO Classification of tumours of soft tissue and bone, 4th ed. Lyon, France: International Agency for Research on Cancer; 2013.
3. Kim J, Ryu S, Kim YJ. Endoscopic submucosal dissection of a colonic calcifying fibrous tumor. Clin Endosc. 2020. https://www.ncbi.nlm.nih.gov/pubmed/31958942. https://doi.org/10.5946/ce.2019.138.
4. Rodríguez-Zarco E, Vallejo-Benítez A, de Soto-Cardenal B, Mora-Cabezas M, Pereira-Gallardo S. Calcifying fibrous tumor of the small bowel [Tumor fibroso calcificante de intestino delgado]. Cir Esp. 2016; 94(4):245–7. https://doi.org/10.1016/j.cireng.2016.03.001.
5. Emanuel P, Qin L, Harpaz N. Calcifying fibrous tumor of small intestine. Ann Diagn Pathol. 2008;12(2):138-41. https://www.ncbi.nlm.nih.gov/pubmed/18325476. https;//doi.org/10.1016/j.anndiagpath.2006.08.006.
6. Wesecki M, Radziuk D, Niemiec S, Waniczek D, Lorenc Z. Calcifying fibrous tumor of the small bowel mesentery in a 27-year old male patient – a case report. Pol Przegl Chir. 2014;86(9):436-9. https://www.ncbi.nlm.nih.gov/pubmed/25527808. https://doi.org/10.2478/pjs-2014-0078.
7. Chorti A, Papavramidis TS, Michalopoulos A. Calcifying fibrous tumor: review of 157 patients reported in international literature. Medicine (Baltimore). 2016;95(20): e3690. https://www.ncbi.nlm.nih.gov/pubmed/27196478. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902420. https://doi.org/10.1097/MD.0000000000003690.
8. Sotiriou S, Papavramidis T, Hytiroglou P. Calcifying fibrous tumor of small bowel causing intussusception. Clin Gastroenterol Hepatol. 2019; 17(8):e95. https://doi.org/10.1016/j.cgh.2018.06.039.
9. Tomassen T, Koelsche C, de Leng WWJ, et al. Calcifying fibrous tumor and inflammatory myofibroblastic tumor are epigenetically related: a comparative genome-wide methylation study. Ann Diagn Pathol. 2019; 41: 102-5. https://doi.org/10.1016/j.anndiagpath.2019.05.013.
10. Voltaggio L, Montgomery EA. Gastrointestinal tract spindle cell lesions—just like real estate, it’s all about location. Mod Pathol. 2015;28 (Suppl 1):S47–66. https://www.ncbi.nlm.nih.gov/pubmed/25560599. https://doi.org/10.1038/modpathol.2014.126.
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