Mucinous Tubular and Spindle Cell Carcinoma of the Kidney

A Case Report and Concise Review of Literature

Authors

  • Hasmin Lisa Corpuz National Kidney and Transplant Institute, Quezon City, Philippines https://orcid.org/0009-0004-7132-6793
  • Valerie Anne Tesoro National Kidney and Transplant Institute, Quezon City, Philippines

Keywords:

mucinous tubular and spindle cell carcinoma, kidney neoplasms, immunohistochemistry, surgical pathology

Abstract

Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare neoplasm of the kidney. Recognition of this rare entity is important with regards to a patient’s prognosis and therapeutic management.

Downloads

Download data is not yet available.

Author Biographies

Hasmin Lisa Corpuz, National Kidney and Transplant Institute, Quezon City, Philippines

Department of Pathology and Laboratory Medicine

Valerie Anne Tesoro, National Kidney and Transplant Institute, Quezon City, Philippines

Department of Pathology and Laboratory Medicine

References

Nathany S, Monappa V. Mucinous tubular and spindle cell carcinoma: a review of histopathology and clinical and prognostic implications. Arch Pathol Lab Med. 2019;144(1):115–8. https://pubmed.ncbi.nlm.nih.gov/30865490. https://doi.org/10.5858/arpa.2017-0506-RS.

Zhao M, He X, Teng X. Mucinous tubular and spindle cell renal cell carcinoma: a review of clinicopathologic aspects. Diagn Pathol. 2015;10(1):168. https://pubmed.ncbi.nlm.nih.gov/26377921. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573286. https://doi.org/10.1186/s13000-015-0402-1.

Fukuta K, Nakanishi R, Moriyama T, et al. High-grade renal mucinous tubular and spindle cell carcinoma. Case Rep Oncol. 2022;15(2):580–5. https://pubmed.ncbi.nlm.nih.gov/35813692. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209964. https://doi.org/10.1159/000524897.

Sokolakis I, Kalogirou C, Frey L, Oelschläger M, Krebs M, Riedmiller H, et al. Mucin-poor mucinous tubular and spindle cell carcinoma of the kidney presented with multiple metastases two years after nephrectomy: an atypical behaviour of a rare, indolent tumour. Case Rep Urol. 2017; 2017:6597592. https://pubmed.ncbi.nlm.nih.gov/29348963. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733991. https://doi.org/10.1155/2017/6597592.

Wu X, Chen Y, Sha J, et al. Renal mucinous tubular and spindle cell carcinoma: A report of 8 cases and review of the literature. Diagn Pathol. 2013;8(1):206. https://pubmed.ncbi.nlm.nih.gov/24330589. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937160. https://doi.org/10.1186/1746-1596-8-206.

Cao W, Huang B, Fei X, et al. Clear cell changes in mucinous tubular and spindle cell carcinoma: cytoplasmic pallor/clearing within tubules, vacuoles or hybrid conventional clear cell carcinoma of kidney. Int J Clin Exp Pathol. 2014;7(7):4350-8. https://pubmed.ncbi.nlm.nih.gov/25120820. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129055.

Alexiev BA, Burke AP, Drachenberg CB, Richards SM, Zou YS. Mucinous tubular and spindle cell carcinoma of the kidney with prominent papillary component, a non-classic morphologic variant. A histologic, immunohistochemical, electron microscopic and fluorescence in situ hybridization study. Pathol Res Pract. 2014;210(7):454–8. https://pubmed.ncbi.nlm.nih.gov/24702883. https://doi.org/10.1016/j.prp.2014.03.002.

Cossu-Rocca P, Eble JN, Delahunt B, et al. Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome y that are prevalent in papillary renal cell carcinoma. Mod Pathol. 2006;19(4):488–93. https://pubmed.ncbi.nlm.nih.gov/16554730. https://doi.org/10.1038/modpathol.3800565.

Gong P, Zhuang Q, Wang X, et al. Mucinous tubular and spindle cell carcinoma of the kidney: five case reports and review of the literature. Oncol Lett. 2020;20(6):337. https://pubmed.ncbi.nlm.nih.gov/33123248. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583836. https://doi.org/10.3892/ol.2020.12201.

Ren Q, Wang L, Al-Ahmadie HA, et al. Distinct genomic copy number alterations distinguish mucinous tubular and spindle cell carcinoma of the kidney from papillary renal cell carcinoma with overlapping histologic features. Am J Surg Pathol. 2018;42(6):767–77. https://pubmed.ncbi.nlm.nih.gov/29462091. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685145. https://doi.org/10.1097/PAS.0000000000001038.

Trpkov K, Hes O, Williamson SR, et al. New developments in existing who entities and evolving molecular concepts: the genitourinary pathology society (GUPS) update on renal neoplasia. Mod Pathol. 2021;34(7):1392–424. https://pubmed.ncbi.nlm.nih.gov/33664427. https://doi.org/10.1038/s41379-021-00779-w.

Banyai D, Vastag F, Yusenko M, Bugert P, Kovacs G. Embryonal origin of MTSCC of kidney may explain its morphological heterogeneity: diagnostic impact of genetic analysis. Anticancer Res. 2017;37(3):1185–90. https://pubmed.ncbi.nlm.nih.gov/28314280. https://doi.org/10.21873/anticanres.11432.

Wang L, Zhang Y, Chen Y-B, et al. VSTM2A overexpression is a sensitive and specific biomarker for mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney. Am J Surg Pathol. 2018;42(12):1571–84. https://pubmed.ncbi.nlm.nih.gov/30285995. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903805. https://doi.org/10.1097/PAS.0000000000001150.

Uchida S, Suzuki K, Uno M, et al. Mucin-poor and aggressive mucinous tubular and spindle cell carcinoma of the kidney: two case reports. Mol Clin Oncol. 2017;7(5):777–82. https://pubmed.ncbi.nlm.nih.gov/29075488. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649005. https://doi.org/10.3892/mco.2017.1400.

Downloads

Published

04/05/2024

How to Cite

Corpuz, H. L., & Tesoro, V. A. (2024). Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: A Case Report and Concise Review of Literature. PJP, 9(1). Retrieved from https://philippinejournalofpathology.org/index.php/PJP/article/view/437

Most read articles by the same author(s)