Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
A Case Report and Concise Review of Literature
DOI:
https://doi.org/10.21141/PJP2024.03Keywords:
mucinous tubular and spindle cell carcinoma, kidney neoplasms, immunohistochemistry, surgical pathologyAbstract
Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare neoplasm of the kidney. Recognition of this rare entity is important with regards to a patient’s prognosis and therapeutic management.
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Nathany S, Monappa V. Mucinous tubular and spindle cell carcinoma: a review of histopathology and clinical and prognostic implications. Arch Pathol Lab Med. 2019;144(1):115–8. https://pubmed.ncbi.nlm.nih.gov/30865490. https://doi.org/10.5858/arpa.2017-0506-RS. DOI: https://doi.org/10.5858/arpa.2017-0506-RS
Zhao M, He X, Teng X. Mucinous tubular and spindle cell renal cell carcinoma: a review of clinicopathologic aspects. Diagn Pathol. 2015;10(1):168. https://pubmed.ncbi.nlm.nih.gov/26377921. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573286. https://doi.org/10.1186/s13000-015-0402-1. DOI: https://doi.org/10.1186/s13000-015-0402-1
Fukuta K, Nakanishi R, Moriyama T, et al. High-grade renal mucinous tubular and spindle cell carcinoma. Case Rep Oncol. 2022;15(2):580–5. https://pubmed.ncbi.nlm.nih.gov/35813692. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209964. https://doi.org/10.1159/000524897. DOI: https://doi.org/10.1159/000524897
Sokolakis I, Kalogirou C, Frey L, Oelschläger M, Krebs M, Riedmiller H, et al. Mucin-poor mucinous tubular and spindle cell carcinoma of the kidney presented with multiple metastases two years after nephrectomy: an atypical behaviour of a rare, indolent tumour. Case Rep Urol. 2017; 2017:6597592. https://pubmed.ncbi.nlm.nih.gov/29348963. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733991. https://doi.org/10.1155/2017/6597592. DOI: https://doi.org/10.1155/2017/6597592
Wu X, Chen Y, Sha J, et al. Renal mucinous tubular and spindle cell carcinoma: A report of 8 cases and review of the literature. Diagn Pathol. 2013;8(1):206. https://pubmed.ncbi.nlm.nih.gov/24330589. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937160. https://doi.org/10.1186/1746-1596-8-206. DOI: https://doi.org/10.1186/1746-1596-8-206
Cao W, Huang B, Fei X, et al. Clear cell changes in mucinous tubular and spindle cell carcinoma: cytoplasmic pallor/clearing within tubules, vacuoles or hybrid conventional clear cell carcinoma of kidney. Int J Clin Exp Pathol. 2014;7(7):4350-8. https://pubmed.ncbi.nlm.nih.gov/25120820. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129055.
Alexiev BA, Burke AP, Drachenberg CB, Richards SM, Zou YS. Mucinous tubular and spindle cell carcinoma of the kidney with prominent papillary component, a non-classic morphologic variant. A histologic, immunohistochemical, electron microscopic and fluorescence in situ hybridization study. Pathol Res Pract. 2014;210(7):454–8. https://pubmed.ncbi.nlm.nih.gov/24702883. https://doi.org/10.1016/j.prp.2014.03.002. DOI: https://doi.org/10.1016/j.prp.2014.03.002
Cossu-Rocca P, Eble JN, Delahunt B, et al. Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome y that are prevalent in papillary renal cell carcinoma. Mod Pathol. 2006;19(4):488–93. https://pubmed.ncbi.nlm.nih.gov/16554730. https://doi.org/10.1038/modpathol.3800565. DOI: https://doi.org/10.1038/modpathol.3800565
Gong P, Zhuang Q, Wang X, et al. Mucinous tubular and spindle cell carcinoma of the kidney: five case reports and review of the literature. Oncol Lett. 2020;20(6):337. https://pubmed.ncbi.nlm.nih.gov/33123248. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583836. https://doi.org/10.3892/ol.2020.12201. DOI: https://doi.org/10.3892/ol.2020.12201
Ren Q, Wang L, Al-Ahmadie HA, et al. Distinct genomic copy number alterations distinguish mucinous tubular and spindle cell carcinoma of the kidney from papillary renal cell carcinoma with overlapping histologic features. Am J Surg Pathol. 2018;42(6):767–77. https://pubmed.ncbi.nlm.nih.gov/29462091. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685145. https://doi.org/10.1097/PAS.0000000000001038. DOI: https://doi.org/10.1097/PAS.0000000000001038
Trpkov K, Hes O, Williamson SR, et al. New developments in existing who entities and evolving molecular concepts: the genitourinary pathology society (GUPS) update on renal neoplasia. Mod Pathol. 2021;34(7):1392–424. https://pubmed.ncbi.nlm.nih.gov/33664427. https://doi.org/10.1038/s41379-021-00779-w. DOI: https://doi.org/10.1038/s41379-021-00779-w
Banyai D, Vastag F, Yusenko M, Bugert P, Kovacs G. Embryonal origin of MTSCC of kidney may explain its morphological heterogeneity: diagnostic impact of genetic analysis. Anticancer Res. 2017;37(3):1185–90. https://pubmed.ncbi.nlm.nih.gov/28314280. https://doi.org/10.21873/anticanres.11432. DOI: https://doi.org/10.21873/anticanres.11432
Wang L, Zhang Y, Chen Y-B, et al. VSTM2A overexpression is a sensitive and specific biomarker for mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney. Am J Surg Pathol. 2018;42(12):1571–84. https://pubmed.ncbi.nlm.nih.gov/30285995. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903805. https://doi.org/10.1097/PAS.0000000000001150. DOI: https://doi.org/10.1097/PAS.0000000000001150
Uchida S, Suzuki K, Uno M, et al. Mucin-poor and aggressive mucinous tubular and spindle cell carcinoma of the kidney: two case reports. Mol Clin Oncol. 2017;7(5):777–82. https://pubmed.ncbi.nlm.nih.gov/29075488. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649005. https://doi.org/10.3892/mco.2017.1400. DOI: https://doi.org/10.3892/mco.2017.1400
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