Brain Metastasis of Papillary Ovarian Adenocarcinoma
Brain metastasis from epithelial ovarian cancer is a rare diagnostic entity with a reported incidence of 1- 2%. Serous epithelial ovarian cancer is usually associated with a poor prognosis and is the most common malignancy metastasizing to the brain. The median time from primary diagnosis to development of cerebral lesions is directly correlated with the initial tumour grade and stage. The median survival after diagnosis of brain metastases is 6 months. It is suggested that brain imaging studies should be included in the follow up of patients after treatment for ovarian carcinoma. We report a case of brain metastasis of ovarian adenocarcinoma 2 years post-surgery and six cycles of chemotherapy.
Piura E, Piura B. Brain metastases from ovarian carcinoma. ISRN Oncol. 2011.;2011: 527453. https://pubmed.ncbi.nlm.nih.gov/22191058. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236423. https://doi.org/10.5402/2011/527453.
Thakur S, Fotedar V, Gupta M. Brain metastasis in epithelial ovarian carcinoma: case series. J Radiat Cancer Res. 2020;11(1):34-7. https://doi.org/10.4103/jrcr.jrcr_11_20.
Kato MK, Tanase Y, Uno M, Ishikawa M, Kato T. Brain metastases from uterine cervical and endometrial cancer. Cancers (Basel). 2021;13(3):519. https://pubmed.ncbi.nlm.nih.gov/33572880. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866278. https://doi.org/10.3390/cancers13030519.
Longo R, Platini C, Eid N, et al. A late, solitary brain metastasis of epithelial ovarian carcinoma. BMC Cancer. 2014;14:543. https://pubmed.ncbi.nlm.nih.gov/25069863. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122771. https://doi.org/10.1186/1471-2407-14-543.
Copyright (c) 2022 PJP
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The Philippine Journal of Pathology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on works made open access at http://philippinejournalofpathology.org