Platelet Derived Growth Factor Receptor- Alpha D842v Mutation in a Spindle Cell Type Gastrointestinal Stromal Tumor: A Case Report

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Jenissa Amor Arceño
Kathleen Chua
Loraine Kay Cabral
Arlie Jean Grace Dumasis
Jose Jasper Andal
Raymundo Lo
Glenda Lyn Pua
Daphne Ang


Molecular genotyping of gastrointestinal stromal tumors is not yet available in the Philippines. We report a case of a 75-year old male with a gastric submucosal mass, who underwent gastroscopic/laparoscopic wedge resection. Histopathology and subsequent immunohistochemical staining with CD117 (CKIT) and DOG1 revealed diagnosis of gastrointestinal stromal tumor, spindle cell variant. On genotyping, the tumor harbored PDGFRA D842V mutation, a subtype resistant to Imatinib treatment. 


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How to Cite
Arceño, J. A., Chua, K., Cabral, L. K., Dumasis, A. J. G., Andal, J. J., Lo, R., Pua, G. L., & Ang, D. (2018). Platelet Derived Growth Factor Receptor- Alpha D842v Mutation in a Spindle Cell Type Gastrointestinal Stromal Tumor: A Case Report. Philippine Journal of Pathology, 3(1), 16. Retrieved from
Case Reports
Author Biographies

Jenissa Amor Arceño, St. Luke's Medical Center Quezon City

Pathology resident

Kathleen Chua, Chinese General Hospital

Surgery Resident

Loraine Kay Cabral, St. Luke's Medical Center Quezon City



Arlie Jean Grace Dumasis, St. Luke's Medical Center - Global City

Medical Technologist

Jose Jasper Andal, St. Luke's Medical Center, Quezon City


Raymundo Lo, St. Luke's Medical Center, Quezon City


Glenda Lyn Pua, St. Luke's Medical Center, Quezon City


Daphne Ang, Institute of Pathology, St. Luke's Medical Center Quezon City



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