Platelet Derived Growth Factor Receptor- Alpha D842v Mutation in a Spindle Cell Type Gastrointestinal Stromal Tumor: A Case Report

  • Jenissa Amor Arceño St. Luke's Medical Center Quezon City
  • Kathleen Chua Chinese General Hospital
  • Loraine Kay Cabral St. Luke's Medical Center Quezon City
  • Arlie Jean Grace Dumasis St. Luke's Medical Center - Global City
  • Jose Jasper Andal St. Luke's Medical Center, Quezon City
  • Raymundo Lo St. Luke's Medical Center, Quezon City
  • Glenda Lyn Pua St. Luke's Medical Center, Quezon City
  • Daphne Ang Institute of Pathology, St. Luke's Medical Center Quezon City
Keywords: gastrointestinal stromal tumor (GIST), platelet derived growth factor receptor-alpha (PDGFRA)

Abstract

Molecular genotyping of gastrointestinal stromal tumors is not yet available in the Philippines. We report a case of a 75-year old male with a gastric submucosal mass, who underwent gastroscopic/laparoscopic wedge resection. Histopathology and subsequent immunohistochemical staining with CD117 (CKIT) and DOG1 revealed diagnosis of gastrointestinal stromal tumor, spindle cell variant. On genotyping, the tumor harbored PDGFRA D842V mutation, a subtype resistant to Imatinib treatment. 

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Author Biographies

Jenissa Amor Arceño, St. Luke's Medical Center Quezon City
Pathology resident
Kathleen Chua, Chinese General Hospital
Surgery Resident
Loraine Kay Cabral, St. Luke's Medical Center Quezon City

Scientist

 

Arlie Jean Grace Dumasis, St. Luke's Medical Center - Global City
Medical Technologist
Jose Jasper Andal, St. Luke's Medical Center, Quezon City
Pathologist
Raymundo Lo, St. Luke's Medical Center, Quezon City
Pathologist
Glenda Lyn Pua, St. Luke's Medical Center, Quezon City
Pathologist
Daphne Ang, Institute of Pathology, St. Luke's Medical Center Quezon City
Pathologist

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Published
2018-02-07
How to Cite
Arceño, J. A., Chua, K., Cabral, L. K., Dumasis, A. J. G., Andal, J. J., Lo, R., Pua, G. L., & Ang, D. (2018). Platelet Derived Growth Factor Receptor- Alpha D842v Mutation in a Spindle Cell Type Gastrointestinal Stromal Tumor: A Case Report. PJP, 3(1), 16. Retrieved from https://philippinejournalofpathology.org/index.php/PJP/article/view/87