Metachronous Primary Cerebral Rhabdomyosarcoma After Treatment of Oral Primitive Neuroectodermal Tumor/ Ewing’s Sarcoma in a School-Aged Girl
A Case Report
DOI:
https://doi.org/10.21141/PJP.2020.13Keywords:
multiple primary malignancies, multiple primary sarcomas, metachronous malignancies, PNET/ Ewing’s sarcoma, rhabdomyosarcoma, immunohistochemistry, fluorescence in situ hybridization, reverse transcription-polymerase chain reactionAbstract
Multiple primary malignancies are defined as two or three malignant neoplasms arising in different organ systems. Several cases of multiple primary malignancies are emerging in recent years due to the advancement in medical therapy and diagnostics. Multiple primary malignancies are not uncommon occurring at 0.7-16% of cancer patients, however, reported cases of multiple primary sarcomas are sparse. Presented in this report is a pediatric patient diagnosed with primary metachronous cerebral
rhabdomyosarcoma after being treated for primitive neuroectodermal tumor/Ewing’s sarcoma of the oral cavity. Despite limited cases addressing multiple primary sarcomas, this entity must not be overlooked as it is associated with a meager outcome compared to an index case of sarcoma alone.
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2. Guerriero A, Giovenali P, La Starza R, et al. Metachronous cardiac and cerebral sarcomas: case report with focus on molecular findings and review of the literature. Human Pathol. 2015;46(3):482-7. https://www.ncbi.nlm.nih.gov/pubmed/25586016. https://doi.org/10.1016/j.humpath.2014.10.028.
3. Warren S, Gates O. Multiple primary malignant tumors, a survey of the literature and statistical study. Am J Cancer 1932;16:1358-1414.
4. Zhang L, Feng L, Cong H, et al. Multiple primary malignant neoplasms: a case report and literature review. Oncol Lett. 2019; 18(4):4210-20. https://www.ncbi.nlm.nih.gov/pubmed/31579423. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757307. https://doi.org/10.3892/ol.2019.10779.
5. Sharma D, Singh G, Kakkar N, Raj S. Second primary malignancy: a retrospective analysis report from a tertiary cancer center of North India. Indian J Cancer. 2016; 53(4), 595-9. https://www.ncbi.nlm.nih.gov/pubmed/28485361. https://doi.org/10.4103/ijc.IJC_542_16.
6. Billroth T. Die allgemeine chirurgische Pathologie und Therapie in 50 Vorlesungen: Handbuch für Studierende und Ärztehttps. Winiwater A, ed. Germany: De Gruyter; 1883. https://doi.org/10.1515/9783111476230. https://www.degruyter.com/view/title/57990.
7. Lex JR, Aoude A, Stevenson JD, et al. Multiple soft tissue sarcomas in a single patient: an international multicentre review. Sarcoma. 2018:Article ID 5392785. https://doi.org/10.1155/2018/5392785.
8. Witt RG, Baldini EH, Raut CP. Screening populations at high risk for soft tissue sarcoma and surveillance following soft tissue sarcoma resection. J Surg Oncol. 2019;120(5):882-90. https://www.ncbi.nlm.nih.gov/pubmed/31432526. https://doi.org/10.1002/jso.25676.
9. Cate F, Bridge JA, Crispens MA, et al. Composite uterine neoplasm with embryonal rhabdomyosarcoma and primitive neuroectodermal tumor components: rhabdomyosarcoma with divergent differentiation, variant of primitive neuroectodermal tumor, or unique entity? Hum Pathol. 2013;44 (4):
656-63. https://www.ncbi.nlm.nih.gov/pubmed/23266445. https://doi.org/10.1016/j.humpath.2012.09.008.
10. Chang L, Enriquez M, Lerman N, Wilson-Smith R. High grade sarcoma, with predominant neuroectodermal and minor embryonal rhabdomyosarcomatous tumor of the uterus: a case report. Gynecol Oncol Rep. 2019;28:128-32. https://www.ncbi.nlm.nih.gov/pubmed/31032392. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479011. https://doi.org/10.1016/j.gore.2019.04.001.
11. Stolnicu S, Goyenaga P, Hincu M, et al. Embryonal (botryoides) rhabdomyosarcoma of the uterus harboring a primitive neuroectodermal tumor component. Int J Gynecol Pathol. 2012;31(4):387-9. https://www.ncbi.nlm.nih.gov/pubmed/22653355. https://doi.org/10.1097/PGP.0b013e31823ff3e6
12. Dundr P, Fischerová D, Povýšil C, et al. Uterine tumors with neuroectodermal differentiation. a report of 4 cases. Pathol Oncol Res. 2010;16(4):601-8. https://www.ncbi.nlm.nih.gov/pubmed/20204716. https://doi.org/10.1007/s12253-010-9249-7.
13. Euscher ED, Deavers MT, Lopez-Terrada D, et al. Uterine tumors with neuroectodermal differentiation: a series of 17 cases and review of the literature. Am J Surg Pathol. 2008;32(2):219-28. https://www.ncbi.nlm.nih.gov/pubmed/18223324. https://doi.org/10.1097/PAS.0b013e318093e421.
14. De Alava E, Lozano M, Sola I, et al. Molecular features in a biphenotypic small cell sarcoma with neuroectodermal and muscle differentiation. Human Pathol. 1998;29(2):181-4. https://www.ncbi.nlm.nih.gov/pubmed/9490279. https://doi.org/10.1016/s0046-8177(98)90230-1.
15. Sorensen PH, Shimada H, Liu XF, Thomas G, Triche TJ. Biphenotypic sarcomas with myogenic and neural differentiation express the Ewing's sarcoma EWS/FLI1 fusion gene. Cancer Res. 1955;55(6):1385-92. https://www.ncbi.nlm.nih.gov/pubmed/7882340.
16. Dome JS, Rodriguez-Galindo C, Spunt SL, Santana VM. Pediatric solid tumors, In Abeloff MD, ed. Abeloff’s Clinical Oncology, 4th ed. Philadelphia, Pennsylvania: Elsevier Health Sciences; 2008.
17. Ackerman LV, Goldblum JR, Lamps LW, McKenney JK, Myers JL, Rosai J. Rosai and Ackerman's Surgical Pathology, 11th ed. Philadelphia, Pennsylvania: Elsevier; 2018.
18. Fletcher CDM, Bridge JA, Hogendroorn PCW, Mertens F, eds. WHO classification of tumours of soft tissue and bone. Lyon: International Agency for Research on Cancer; 2013.
19. Skapek SX, Ferrari A, Gupta AA, et al. (2019). Rhabdomyosarcoma. Nature Rev Dis Primers. 2019;5(1):1. https://www.ncbi.nlm.nih.gov/pubmed/30617281. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456566. https://doi.org/10.1038/s41572-018-0051-2.
20. Schiffman JD, Wright J. Ewing's sarcoma and second malignancies. Sarcoma, 2011: Article ID 736841. https://doi.org/10.1155/2011/736841.
Published
12/29/2020
How to Cite
Gonong, D. A., & Madrid, M. (2020). Metachronous Primary Cerebral Rhabdomyosarcoma After Treatment of Oral Primitive Neuroectodermal Tumor/ Ewing’s Sarcoma in a School-Aged Girl: A Case Report. PJP, 5(2), 53–59. https://doi.org/10.21141/PJP.2020.13
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