A Case Report on Carcinosarcoma of the Pancreas with a Concise Literature Review
DOI:
https://doi.org/10.21141/PJP.2022.11Keywords:
pancreatic carcinosarcoma, pancreas, carcinosarcoma, immunohistochemistry, surgical pathology, diagnosisAbstract
Carcinosarcoma is a rare neoplasm that most commonly affects the uterus. In the pancreas, fewer than thirty cases are reported worldwide. We present a 47-year-old female with epigastric pain, and jaundice. Histopathology revealed a pancreatic head mass showing a biphasic tumor composed of seventy percent Pancreatic Ductal Adenocarcinoma, and thirty percent High Grade Sarcoma with immunohistochemistry using Pancytokeratin, Vimentin, Desmin, S-100, Smooth Muscle Actin, CD34, and Ki-67.
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References
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7 Okamura J, Sekine S, Nara S, Ojima H, Shimada K, Kanai Y, et al. Intraductal carcinosarcoma with Heterologous Mesenchymal Component Originating in Intraductal Papillary-Mucinous Carcinoma and Osteosarcoma cells arising from IPMC cells. J Clin Pathol. 2010; 63:266-269. DOI:10.1136/jcp.2009.071613.
8 Nakano T, Sonobe H, Usui T, Yamanaka K, Ishizuka T, Nishimura E, et al. Immunohistochemistry and K-RAS Sequence of Pancreatic Carcinosarcoma. Pathology International. 2008; 58: 672–677. DOI:10.1111/j.1440-1827.2008.02289.x.
9 Jia Z, Zhang K, Huang RH, Zhou XG, Jiang L. Pancreatic carcinosarcoma with rare long-term survival: Case report and review of the literature. Medicine (Baltimore). 2017 Jan;96(4): e5966. PMID: 28121946; PMCID: PMC5287970. DOI: 10.1097/MD.0000000000005966.
10 Liu Y, Hao H, Guo X, Xu J, Kang L, Zheng G, et al. Rare pancreatic carcinosarcoma in a patient with medical history of esophageal cancer: A case report and literature review. Medicine (Baltimore). 2019 Apr;98(16):e15238. PMID: 31008956; PMCID: PMC6494381. DOI: 10.1097/MD.0000000000015238.
11 Salibay CJ, Rewerska J, Gupta S, Ree N. Primary Carcinosarcoma of the Pancreas With CD10-Positive Sarcoma Component. J Investig Med High Impact Case Rep. 2017 Nov 6;5(4):2324709617740906. PMID: 29152519; PMCID: PMC5680943. DOI: 10.1177/2324709617740906.
12 Shi HY, Xie J, Miao F. Pancreatic carcinosarcoma: first literature report on computed tomography imaging. World J Gastroenterol. 2015 Jan 28;21(4):1357-61. PMID: 25632213; PMCID: PMC4306184. DOI: 10.3748/wjg.v21.i4.1357.
13 Cicy PJ, Sansho EU, Letha V, Umman P, Varghese S, Kurien J. Carcinosarcoma of the Pancreas: A Case Report with Emphasis on Histopathology and Review of the Literature. International J. of Healthcare and Biomedical Research. 2015 July 04; Volume: 03, Issue: 04, Pages 76-83.
14 Oymaci E, Argon A, Coskun A, Ucar AD, Carti E, Erkan N, et al. Pancreatic Carcinosarcoma: Case Report of a Rare Type of Pancreatic Neoplasia. JOP. J Pancreas (Online). 2013 Mar 10; 14(2):212-215.
15 Palaniappan M, Jose WM, Bindhu MR, Sudheer OV, Pavithran K. Carcinosarcoma of the Pancreas: Report of a Case with a Concise Review of the Literature. Journal of Clinical and Diagnostic Research. 2011 June; Vol-5(3): 621-624.
2 Still S, Becerra C, Clement-Kruzel S, Cavaness K. Locally advanced carcinosarcoma of the pancreas, Proc (Bayl Univ Med Cent). 2018 Mar 20; 31(2):210-212.
3 Li J, Wei T, Zhang J, Wei S, Chen Q, Chen BW, Zhou Y, et al. Carcinosarcoma of the pancreas: comprehensive clinicopathological and molecular characterization. HPB. 2020. Jan; DOI: https://doi.org/10.1016/j.hpb.2020.01.017
4 Ruess D, Kayser C, Neubauer J, Fichtner-Feigl S, Hopt UT, Wittel UA. Carcinosarcoma of the Pancreas Case Report with Comprehensive Literature Review. Pancreas. 2017;46:1225-1233. DOI: 10.1111/his.12975
5 Bai Q, Zhang X, Zhu X, Wang L, Huang D, Cai X, et al. Pancreatic Carcinosarcoma with the same KRAS Gene Mutation in both Carcinomatous and Sarcomatous Components: Molecular Evidence for Monoclonal Origin of the Tumour. Histopathology. 2016; DOI: 10.1111/his.12975
6 Kim HS, Joo SH, Yang DM, Lee SH, Choi SH, Lim SJ. Carcinosarcoma of the Pancreas: A Unique Case with Emphasis on Metaplastic Transformation and the Presence of Undifferentiated Pleomorphic High-Grade Sarcoma. J Gastrointestin Liver Dis. 2011 Jun; Vol. 20 No 2, 197-200.
7 Okamura J, Sekine S, Nara S, Ojima H, Shimada K, Kanai Y, et al. Intraductal carcinosarcoma with Heterologous Mesenchymal Component Originating in Intraductal Papillary-Mucinous Carcinoma and Osteosarcoma cells arising from IPMC cells. J Clin Pathol. 2010; 63:266-269. DOI:10.1136/jcp.2009.071613.
8 Nakano T, Sonobe H, Usui T, Yamanaka K, Ishizuka T, Nishimura E, et al. Immunohistochemistry and K-RAS Sequence of Pancreatic Carcinosarcoma. Pathology International. 2008; 58: 672–677. DOI:10.1111/j.1440-1827.2008.02289.x.
9 Jia Z, Zhang K, Huang RH, Zhou XG, Jiang L. Pancreatic carcinosarcoma with rare long-term survival: Case report and review of the literature. Medicine (Baltimore). 2017 Jan;96(4): e5966. PMID: 28121946; PMCID: PMC5287970. DOI: 10.1097/MD.0000000000005966.
10 Liu Y, Hao H, Guo X, Xu J, Kang L, Zheng G, et al. Rare pancreatic carcinosarcoma in a patient with medical history of esophageal cancer: A case report and literature review. Medicine (Baltimore). 2019 Apr;98(16):e15238. PMID: 31008956; PMCID: PMC6494381. DOI: 10.1097/MD.0000000000015238.
11 Salibay CJ, Rewerska J, Gupta S, Ree N. Primary Carcinosarcoma of the Pancreas With CD10-Positive Sarcoma Component. J Investig Med High Impact Case Rep. 2017 Nov 6;5(4):2324709617740906. PMID: 29152519; PMCID: PMC5680943. DOI: 10.1177/2324709617740906.
12 Shi HY, Xie J, Miao F. Pancreatic carcinosarcoma: first literature report on computed tomography imaging. World J Gastroenterol. 2015 Jan 28;21(4):1357-61. PMID: 25632213; PMCID: PMC4306184. DOI: 10.3748/wjg.v21.i4.1357.
13 Cicy PJ, Sansho EU, Letha V, Umman P, Varghese S, Kurien J. Carcinosarcoma of the Pancreas: A Case Report with Emphasis on Histopathology and Review of the Literature. International J. of Healthcare and Biomedical Research. 2015 July 04; Volume: 03, Issue: 04, Pages 76-83.
14 Oymaci E, Argon A, Coskun A, Ucar AD, Carti E, Erkan N, et al. Pancreatic Carcinosarcoma: Case Report of a Rare Type of Pancreatic Neoplasia. JOP. J Pancreas (Online). 2013 Mar 10; 14(2):212-215.
15 Palaniappan M, Jose WM, Bindhu MR, Sudheer OV, Pavithran K. Carcinosarcoma of the Pancreas: Report of a Case with a Concise Review of the Literature. Journal of Clinical and Diagnostic Research. 2011 June; Vol-5(3): 621-624.
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Published
06/28/2022
How to Cite
Santos, C., & Samonte, R. S. M. (2022). A Case Report on Carcinosarcoma of the Pancreas with a Concise Literature Review. PJP, 7(1), 57–64. https://doi.org/10.21141/PJP.2022.11
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Case Reports
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The Philippine Journal of Pathology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on works made open access at http://philippinejournalofpathology.org
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