A Case Report on Carcinosarcoma of the Pancreas with a Concise Literature Review

  • Christine Santos National Kidney and Transplant Institute, East Avenue, Diliman, Quezon City https://orcid.org/0000-0002-5476-3578
  • Rosalie Sabina Michiko Samonte National Kidney and Transplant Institute, East Avenue, Diliman, Quezon City
Keywords: pancreatic carcinosarcoma, pancreas, carcinosarcoma, immunohistochemistry, surgical pathology, diagnosis

Abstract

Carcinosarcoma is a rare neoplasm that most commonly affects the uterus. In the pancreas, fewer than thirty cases are reported worldwide. We present a 47-year-old female with epigastric pain, and jaundice. Histopathology revealed a pancreatic head mass showing a biphasic tumor composed of seventy percent Pancreatic Ductal Adenocarcinoma, and thirty percent High Grade Sarcoma with immunohistochemistry using Pancytokeratin, Vimentin, Desmin, S-100, Smooth Muscle Actin, CD34, and Ki-67.

Downloads

Download data is not yet available.

Author Biographies

Christine Santos, National Kidney and Transplant Institute, East Avenue, Diliman, Quezon City

Department of Pathology and Laboratory Medicine

Rosalie Sabina Michiko Samonte, National Kidney and Transplant Institute, East Avenue, Diliman, Quezon City

Department of Pathology and Laboratory Medicine

References

Bosman FT, Carneiro F, Hruban RH, eds. WHO Classification of Tumors of the Digestive System, 5th ed. Lyon: International Agency for Research on Cancer. 2019; pp322-329.

Still S, Becerra C, Clement-Kruzel S, Cavaness K. Locally advanced carcinosarcoma of the pancreas, Proc (Bayl Univ Med Cent). 2018 Mar 20; 31(2):210-212.

Li J, Wei T, Zhang J, Wei S, Chen Q, Chen BW, Zhou Y, et al. Carcinosarcoma of the pancreas: comprehensive clinicopathological and molecular characterization. HPB. 2020. Jan; DOI: https://doi.org/10.1016/j.hpb.2020.01.017

Ruess D, Kayser C, Neubauer J, Fichtner-Feigl S, Hopt UT, Wittel UA. Carcinosarcoma of the Pancreas Case Report with Comprehensive Literature Review. Pancreas. 2017;46:1225-1233. DOI: 10.1111/his.12975

Bai Q, Zhang X, Zhu X, Wang L, Huang D, Cai X, et al. Pancreatic Carcinosarcoma with the same KRAS Gene Mutation in both Carcinomatous and Sarcomatous Components: Molecular Evidence for Monoclonal Origin of the Tumour. Histopathology. 2016; DOI: 10.1111/his.12975

Kim HS, Joo SH, Yang DM, Lee SH, Choi SH, Lim SJ. Carcinosarcoma of the Pancreas: A Unique Case with Emphasis on Metaplastic Transformation and the Presence of Undifferentiated Pleomorphic High-Grade Sarcoma. J Gastrointestin Liver Dis. 2011 Jun; Vol. 20 No 2, 197-200.

Okamura J, Sekine S, Nara S, Ojima H, Shimada K, Kanai Y, et al. Intraductal carcinosarcoma with Heterologous Mesenchymal Component Originating in Intraductal Papillary-Mucinous Carcinoma and Osteosarcoma cells arising from IPMC cells. J Clin Pathol. 2010; 63:266-269. DOI:10.1136/jcp.2009.071613.

Nakano T, Sonobe H, Usui T, Yamanaka K, Ishizuka T, Nishimura E, et al. Immunohistochemistry and K-RAS Sequence of Pancreatic Carcinosarcoma. Pathology International. 2008; 58: 672–677. DOI:10.1111/j.1440-1827.2008.02289.x.

Jia Z, Zhang K, Huang RH, Zhou XG, Jiang L. Pancreatic carcinosarcoma with rare long-term survival: Case report and review of the literature. Medicine (Baltimore). 2017 Jan;96(4): e5966. PMID: 28121946; PMCID: PMC5287970. DOI: 10.1097/MD.0000000000005966.

Liu Y, Hao H, Guo X, Xu J, Kang L, Zheng G, et al. Rare pancreatic carcinosarcoma in a patient with medical history of esophageal cancer: A case report and literature review. Medicine (Baltimore). 2019 Apr;98(16):e15238. PMID: 31008956; PMCID: PMC6494381. DOI: 10.1097/MD.0000000000015238.

Salibay CJ, Rewerska J, Gupta S, Ree N. Primary Carcinosarcoma of the Pancreas With CD10-Positive Sarcoma Component. J Investig Med High Impact Case Rep. 2017 Nov 6;5(4):2324709617740906. PMID: 29152519; PMCID: PMC5680943. DOI: 10.1177/2324709617740906.

Shi HY, Xie J, Miao F. Pancreatic carcinosarcoma: first literature report on computed tomography imaging. World J Gastroenterol. 2015 Jan 28;21(4):1357-61. PMID: 25632213; PMCID: PMC4306184. DOI: 10.3748/wjg.v21.i4.1357.

Cicy PJ, Sansho EU, Letha V, Umman P, Varghese S, Kurien J. Carcinosarcoma of the Pancreas: A Case Report with Emphasis on Histopathology and Review of the Literature. International J. of Healthcare and Biomedical Research. 2015 July 04; Volume: 03, Issue: 04, Pages 76-83.

Oymaci E, Argon A, Coskun A, Ucar AD, Carti E, Erkan N, et al. Pancreatic Carcinosarcoma: Case Report of a Rare Type of Pancreatic Neoplasia. JOP. J Pancreas (Online). 2013 Mar 10; 14(2):212-215.

Palaniappan M, Jose WM, Bindhu MR, Sudheer OV, Pavithran K. Carcinosarcoma of the Pancreas: Report of a Case with a Concise Review of the Literature. Journal of Clinical and Diagnostic Research. 2011 June; Vol-5(3): 621-624.

Published
2022-06-28
How to Cite
Santos, C., & Samonte, R. S. M. (2022). A Case Report on Carcinosarcoma of the Pancreas with a Concise Literature Review. PJP, 7(1), 57-64. https://doi.org/10.21141/PJP.2022.11