HPV-Independent Gastric Type Adenocarcinoma of the Uterine Cervix presenting as Ovarian Masses

A Case Report and Review of Literature

Keywords: cervical adenocarcinoma, gastric-type cervical adenocarcinoma, hpv-independent cervical adenocarcinoma

Abstract

Adenocarcinoma, HPV-independent, gastric type of the uterine cervix comprises only 10-15% of all cervical adenocarcinomas. A rare case of which, with metastasis to the uterine corpus and bilateral ovaries, is described. A 43-year-old female (G0P0) presented with menorrhagia and right flank pain radiating to the hypogastrium. Physical examination revealed an immovable, tender mass at the right lower quadrant with a nodular, firm cervix. Transabdominal ultrasound revealed multiseptated ovarian masses. The right and left ovaries were sent for frozen section and was diagnosed as Mucinous Cystadenoma and Mature Cystic Teratoma, respectively. Hysterectomy revealed a detached and fragmented cervix with irregular, abnormally shaped glands lined by a single layer of columnar cells with bland, basally located nuclei and clear cytoplasm associated with desmoplasia, findings which were also seen in the endomyometrium and ovaries. These tumor cells were CK7 positive and negative for ER, PR, CK20 and CDX2. The patient died six months after surgery. The presence of benign appearing glands is a diagnostic challenge. Despite the appearance, they may be malignant and should be investigated rigorously.

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Author Biographies

Joseph Antoine Chatto, Governor Celestino Gallares Memorial Hospital, Tagbilaran City, Bohol, Philippines

Medical Officer IV, Department of Pathology

Annette Salillas, Governor Celestino Gallares Memorial Hospital, Tagbilaran City, Bohol, Philippines

Chairman, Department of Pathology

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Published
2021-06-29
How to Cite
Chatto, J. A., & Salillas, A. (2021). HPV-Independent Gastric Type Adenocarcinoma of the Uterine Cervix presenting as Ovarian Masses: A Case Report and Review of Literature. PJP, 6(1), 50-55. https://doi.org/10.21141/PJP.2021.06