TY - JOUR AU - Arceño, Jenissa Amor AU - Chua, Kathleen AU - Cabral, Loraine Kay AU - Dumasis, Arlie Jean Grace AU - Andal, Jose Jasper AU - Lo, Raymundo AU - Pua, Glenda Lyn AU - Ang, Daphne PY - 2018/02/07 Y2 - 2024/03/28 TI - Platelet Derived Growth Factor Receptor- Alpha D842v Mutation in a Spindle Cell Type Gastrointestinal Stromal Tumor: A Case Report JF - PJP JA - Phil Journal Path VL - 3 IS - 1 SE - Case Reports DO - UR - https://philippinejournalofpathology.org/index.php/PJP/article/view/87 SP - 16 AB - <p style="text-align: justify;">Molecular genotyping of gastrointestinal stromal tumors is not yet available in the Philippines. We report a case of a 75-year old male with a gastric submucosal mass, who underwent gastroscopic/laparoscopic wedge resection. Histopathology and subsequent immunohistochemical staining with CD117 (CKIT) and DOG1 revealed diagnosis of gastrointestinal stromal tumor, spindle cell variant. On genotyping, the tumor harbored PDGFRA D842V mutation, a subtype resistant to Imatinib treatment. </p> ER -