TY - JOUR AU - Damian, Karen AU - Cancio, Jonathan Emmanuel PY - 2021/06/29 Y2 - 2024/03/29 TI - Disseminated Double-Hit Lymphoma in a Young Adult JF - PJP JA - Phil Journal Path VL - 6 IS - 1 SE - Autopsy Vault DO - 10.21141/PJP.2021.07 UR - https://philippinejournalofpathology.org/index.php/PJP/article/view/235 SP - 56-61 AB - <p>High-grade B-cell lymphoma with MYC and BCL2 and-or BCL6 rearrangements, also called double-hit lymphoma, is an aggressive mature B-cell lymphoma that carries both MYC and BCL2 and/or BCL6 translocations.&nbsp; This can present as a diagnostic challenge since clinical characteristics, morphology and immunophenotype are not accurate indicators of underlying genetic aberrations in this type of lymphoma.&nbsp; We report a case of a 25-year-old male who presented with a one-year history of cough, gradually increasing abdominal girth and jaundice.&nbsp; Definitive diagnosis was made post-mortem with additional ancillary studies using immunohistochemistry staining and&nbsp; fluorescent in-situ hybridization studies.&nbsp;</p> ER -