TY - JOUR AU - Medalla, Ivy Mae AU - Gepte, Maria Beatriz AU - Pido, Qareem AU - Ang, Daphne PY - 2021/06/29 Y2 - 2024/03/28 TI - Cost-Effectiveness of Limited Screening Panel for Acute Lymphoblastic Leukemia Diagnosis in a Resource-Limited Setting JF - PJP JA - Phil Journal Path VL - 6 IS - 1 SE - Original Articles DO - 10.21141/PJP.2021.04 UR - https://philippinejournalofpathology.org/index.php/PJP/article/view/211 SP - 27-30 AB - <p><strong>Background:</strong> Flow cytometry is an invaluable tool in the diagnostic evaluation of acute leukemia and post therapy monitoring; however, majority of Filipino population cannot afford the cost. The use of a minimal screening panel which is both cost-effective and provides an accurate diagnosis of acute lymphoblastic leukemia is seen as an alternative.</p><p><strong>Objectives: </strong>We aim to determine the cost-effectiveness and accuracy of using a minimal screening panel for the diagnosis of acute lymphoblastic leukemia (ALL).</p><p><strong>Methodology:</strong> We selected a limited panel of 9 antibodies comprising of CD45/CD19/CD20/CD10/HLA-DR/CD34/cCD3/cCD79a/cTdt and retrospectively reviewed newly diagnosed cases of B-cell and T-cell ALL from September 2016 to December 2019 using this panel.</p><p><strong>Results: </strong>Out of 719 bone marrow aspirates submitted for basic leukemia flow cytometric analysis we identified 268 ALL cases (239 B-ALL and 29 T-ALL).</p><p>In all cases, a diagnosis was established using the limited panel. Compared to the current cost of our comprehensive panel (₱ 9,903.60). This limited panel cost ₱ 3,062.29, that offers a 69.08% savings per test, which translated to a ₱1.2 million savings a year (for an average of 180 annual cases).</p><p><strong>Conclusion: </strong>We underscore the utility of a limited panel for the diagnosis of ALL. Although this panel remains to be assessed with a larger validation cohort, its application in resource-limited developing countries is diagnostically useful and cost-effective.</p><p><strong>Recommendation:</strong> The use of a limited panel of 9 antibodies is recommended as a screening panel for patients who are highly suspected of having ALL both clinically and initial bone marrow smear assessment.</p> ER -