@article{Tindoc_Villanueva III_Geraldino_2019, title={Correlation of Tumor-associated Leukocytes with Prognosis of Colorectal Carcinoma based on Pathologic Stage}, volume={4}, url={https://philippinejournalofpathology.org/index.php/PJP/article/view/151}, DOI={10.21141/PJP.2019.12}, abstractNote={<p style="text-align: justify;"><strong>Objectives</strong> To perform a pilot study investigating the presence of correlation between the different mean tumor-associated leukocyte counts and the prognosis of colorectal cancer based on pathologic stage.</p><p style="text-align: justify;"><strong>Methodology</strong> A cross-sectional study design, involving colorectal carcinoma cases in the Philippine General Hospital from 2015-2016. Proportional allocation stratified random sampling was done, with pathologic stage (AJCC 7th Edition) as the stratifying variable, collecting a total of 59 samples. Tissue sections from the samples were evaluated for the different tumor-associated lymphocyte counts. Correlation coefficients were computed to determine their correlation with pathologic stage as surrogate marker for prognosis.</p><p style="text-align: justify;"><strong>Results</strong> Of the myriad populations counted within and around the tumor mass, total lymphocyte, cytotoxic T-cell (CD8+ T-cell), neutrophil, macrophage, and plasma cell populations have significant correlation with pathologic stage as surrogate marker for prognosis of colorectal carcinoma.</p><p style="text-align: justify;"><strong>Conclusion</strong> The immune system appears to have a significant role in the natural history of colorectal carcinoma. The tumor-infiltrating lymphocytic population and especially the CD8+ T-cell subset, neutrophils, and macrophages are correlated with better prognosis. The same observation can be seen with the peritumoral CD8+ T-cells, neutrophils, macrophages, and plasma cells.</p>}, number={2}, journal={PJP}, author={Tindoc, John Anthony and Villanueva III, Emilio and Geraldino, Nelson}, year={2019}, month={Nov.}, pages={24–30} }