Malignant Glomus Tumor of the Heart in a 64-Year Old Male Presenting with Stroke

Othaniel Philip Balisan, C Philip Teomar Radin II, Randell Arias, Felipe Templo, Jr.


Glomus tumor is a soft tissue neoplasm usually observed as a solitary, or sometimes multicentric painful mass, that rarely occurs extracutaneously. We describe a rare caseof malignant glomus tumor of the heart in a 64-year old male diagnosed with a left ventricular mass. Echocardiography and color flow Doppler revealed a large echogenic mobile structure in the left ventricular cavity that was surgically resected. The histopathologic diagnosis was malignant cardiac glomus tumor. We describe the histopathology, differential diagnosis and clinical presentation of this extremely rare primary cardiac tumor.


cardiac tumor, left ventricular mass, glomus tumor, malignant cardiac glomangioma, embolic stroke

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Gombos Z, Zhang PJ. Glomus tumor. Arch Path Lab Med. 2008;132(9):1448-52. PMID: 18788860.

De Chiara A, Apice G, Mori S, et al. Malignant glomus tumour: a case report and review of the literature. Sarcoma, 2003;7(2):87-91. PMCID: PMC2395518.

Ariizumi Y, Koizumi H, Hoshikawa M, et al. A primary pulmonary glomus tumor: A case report and review of literature. Case reports in pathology. 2012;2012. Article ID 782304.

Jang SH, Cho HD, Lee JH, et al. Mediastinal glomus tumor: a case report and literature review. J Pathol Transl Med. 2015;49(6):520-4. PMID: 26265686. PMCID: PMC4696525.

Kang G, Park HJ, Kim JY, et al. Glomus tumor of the stomach: a clinicopathologic analysis of 10 cases and review of literature. Gut Liver. 2012;6(1):52-7. PMID: 22375171. PMCID: PMC3286739.

Katz VL, Askin FB, Bosch BD. Glomus tumor of the vulva: a case report. Obstet Gynecol. 1986;67(3 Suppl): 43S-5. PMID: 3003639.

Dagur G, Warren K, Miao Y, Singh N, Suh Y, Khan SA. Unusual glomus tumor of the penis. Curr Urol. 2016;9(3):113–8. PMID: 27867327. PMCID: PMC5109964.

Stangl R. Glomus tumors in the eye region. Ber Zusammenkunft Dtsch Ophthalmol Ges. 1977;74:884-6. PMID: 195570.

Karapinar K, Kaplan S, Zengin NI, Yucel E. Glomus tumor of the heart: report of an extreme case. Chirurgia. 2005;18(3):125-8.

Riesner K, Böcker W. [Cardiac glomus tumor. Light- and electron microscopic investigations (author’s transl)]. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975;84(1):59­66. PMID: 171867.

Elkrinawi R, Usta E, Baumbach H, Franke UF. Late recurrence of a cardiac glomus tumor. Thorac Cardiovasc Surg. 2012;60(4):305-6. PMID: 21452115.

Folpe AL, Fanburg-Smith JC, Miettinen M, Weiss SW. Atypical and malignant glomus tumors: analysis of 52 cases, with a proposal for the reclassification of glomus tumors. Am J Surg Path. 2001;25(1):1-12. PMID: 11145243.

Brems H, Park C, Maertens O, Pemov A, Messiaen L, et al. Glomus tumors in neurofibromatosis type 1: genetic, functional, and clinical evidence of a novel association. Cancer Res. 2009;69:(18):7393-401. PMID: 19738042. PMCID: PMC2747722.

Dias RR, Fernandes F, Ramires FJ, Mady C, Albuquerque CP, Jatene FB. Mortality and embolic potential of cardiac tumors. Arq Bras Cardiol. 2014;103(1):13-8. PMID: 25029470. PMCID: PMC4126756.

Hoffmeier A, Sindermann JR, Scheld HH, Martens S. Cardiac tumors-diagnosis and surgical treatment. Dtsch Arztebl Int. 2014;111(12):205-11. PMCID: PMC3983698.

Miller DV, Tazelaar HD. Cardiovascular pseudoneoplasms. Arch Pathol Lab Med. 2010;134(3):362-8. PMID: 20196664.


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